Etter at EA kunne avsløre at Dragon Age: Inquisition er Biowares beste spillansering noensinne har mange spillere bekymret seg for at dette skal påvirke gameplayet i det kommende Mass Effect 4. Aaryn Flynn hos Bioware har derfor gått ut på Neogaf-forumet for å berolige alle. Blant annet brukte han fartøyet Mako som eksempel på at spillet vil låne fra sin egen historie i stedet for å hente innflytelse fra Dragon Age:
"The next Mass Effect will be (and should be) drawing on its own rich and successful past more than what DAI would say it should do. Take the Mako, something we've already shown in prototype form. We had that in ME1, and bringing it back is more related to a feeling that we can do it much better than we did before and fulfill the original promise of that gameplay.
That has nothing to do with DAI. In fact, I'd go so far as to say that dropping the older consoles has had more impact on the overall gameplay goals of the next Mass Effect game than what DAI successfully accomplished. We're very proud of what DAI has achieved, but that does not set a "template" for what every other game we make needs to be. Each game franchise needs to innovate and improve their experience based on what's best for it, not just what another game had success with because "well that was successful."
Mass Effect 4 forventes lansering til PC, Xbox One og Playstation 4, men det er ikke bekreftet.