Spilltittelen har såvisst gitt en pekepin på at Uncharted 4: A Thief's End kan bli det siste spillet i serien om Nathan Drake, og nå er det offisielt bekreftet. Naughty Dogs lead designer, Kurt Mangenau, sa nylig i et intervju med Gamespot:
"[Druckmann and Bruce Straley], our directors, they have a vision [for Uncharted 4]. We are fulfilling that vision and it's going to be awesome. It's Nathan Drake's final chapter, so I think fans are going to be happy."
Faktum er at Druckmann selv også har sagt det samme til nettopp Gamespot:
"The first three games were the set-up, and if we were to do one more, how would we top it all off? How would we bring Nathan Drake's journey to a close? Everything we're doing [with Uncharted 4] is constructed towards that; Bringing closure to a very long journey."
Skulle Uncharted-serien fortsette videre, vil det altså være uten Nathan Drake i hovedrollen.
